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首页> 外文OA文献 >Distinct Elevation of Levels of Anti-Caenorhabditis elegans Antibody in Sera of Patients with Inflammatory Bowel Disease
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Distinct Elevation of Levels of Anti-Caenorhabditis elegans Antibody in Sera of Patients with Inflammatory Bowel Disease

机译：炎症性肠病患者血清中抗秀丽隐杆线虫抗体水平的明显升高

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Dysregulation of immune responses to intestinal exogenous antigens contributes to the pathogenesis of inflammatory bowel disease, but the specific antigen responsible for the pathogenesis of inflammatory bowel disease is unknown. We measured serum antibody titers against Caenorhabditis elegans antigens. Immunoglobulin G (IgG) and IgG subclass anti-C. elegans antibodies in serum samples from 29 patients with ulcerative colitis, 30 patients with Crohn's disease, 7 patients with intestinal Behçet's disease, and 11 healthy controls were measured by enzyme-linked immunosorbent assay. Serum IgG and IgG2 antibody titers against C. elegans were significantly higher in patients with inflammatory bowel disease than in controls. Antibody levels were not affected by age, gender, disease activity, extent of disease, or small bowel involvement. The anti-C. elegans antibody titer was significantly lower in patients with Crohn's disease taking mesalazine or sulfasalazine than in patients not taking these drugs. The increased immune responses to C. elegans found in patients with inflammatory bowel disease reflect dysregulated immune responses to enteric antigens, which might play a role in the pathogenesis of inflammatory bowel disease.
机译：对肠道外源性抗原的免疫反应失调有助于炎症性肠病的发病机理，但导致炎症性肠病的发病机理的特异性抗原尚不清楚。我们测量了针对秀丽隐杆线虫抗原的血清抗体滴度。免疫球蛋白G（IgG）和IgG亚类抗C.通过酶联免疫吸附测定法检测了29例溃疡性结肠炎患者，30例克罗恩病患者，7例肠道白塞病患者和11例健康对照者血清样品中的线虫抗体。在炎症性肠病患者中，针对秀丽隐杆线虫的血清IgG和IgG2抗体滴度明显高于对照组。抗体水平不受年龄，性别，疾病活动，疾病程度或肠小肠感染的影响。反C。服用美沙拉嗪或柳氮磺吡啶的克罗恩病患者中，线虫抗体滴度明显低于未服用这些药物的患者。在炎症性肠病患者中发现的对秀丽隐杆线虫的免疫反应增加反映了对肠抗原的免疫反应失调，这可能在炎症性肠病的发病机理中起作用。

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